GALNT11 Antibody, HRP conjugated

Datasheet

Code	CSB-PA847687LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) GALNT11 Polyclonal antibody

Uniprot No.

Q8NCW6

Target Names

GALNT11

Alternative Names

A430075I06Rik antibody; AI648252 antibody; E430002F06Rik antibody; FLJ21634 antibody; GalNAc Transferase 11 antibody; GalNAc-T11 antibody; GalNAcT11 antibody; GALNT11 antibody; GLT11_HUMAN antibody; MGC71630 antibody; Polypeptide GalNAc transferase 11 antibody; Polypeptide N-acetylgalactosaminyltransferase 11 antibody; pp-GaNTase 11 antibody; Protein-UDP acetylgalactosaminyltransferase 11 antibody; tcag7.1057 antibody; UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11 antibody; UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11) antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Polypeptide N-acetylgalactosaminyltransferase 11 protein (420-606AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO).

Gene References into Functions

possible role in the deterioration of kidney function [meta-analysis] PMID: 25493955
evidence suggests that CLL patient samples harbor aberrant O-glycosylation highlighted by Tn antigen expression and that the over-expression of GALNT11 constitutes a new molecular marker for CLL PMID: 24076351
GALNT11, the human ortholog to Drosophila melanogaster pgant35A, was shown not to support rescue of the l(2)35Aa lethality during Drosophila embryogenesis. PMID: 20422447
Single nucleiotide polymorphism in the GALNT11 genes were investigated to assess allele frequencies in different populations. This SNP would be useful marker for forensic individualization, in particular, as ancestry-informative markers. PMID: 20547088

Involvement in disease

Defects in GALNT11 may be a cause of heterotaxy, a congenital heart disease resulting from abnormalities in left-right (LR) body patterning.

Subcellular Location

Golgi apparatus membrane; Single-pass type II membrane protein.

Protein Families

Glycosyltransferase 2 family, GalNAc-T subfamily

Tissue Specificity

Highly expressed in kidney. Expressed at intermediate level in brain, heart and skeletal muscle. Weakly expressed other tissues. In kidney, it is strongly expressed in tubules but not expressed in glomeruli.

Database Links

HGNC: 19875

OMIM: 615130

KEGG: hsa:63917

STRING: 9606.ENSP00000315835

UniGene: Hs.647109

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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